In this photo combo, at left, in an Oct. 8, 2011 file photo, Penn State president Graham Spanier walks on the field before an NCAA college football game in State College, Pa. At right, former Penn State University assistant football coach Jerry Sandusky leaves the Centre County Courthouse in custody after being found guilty of multiple charges of child sexual abuse in Bellefonte, Pa., Friday, June 22, 2012. CNN says it has seen emails showing Spanier agreed not to take allegations of sex abuse against Sandusky to authorities but worried they'd be "vulnerable" for failing to report it. CNN says the emails followed a graduate assistant's 2001 report of seeing Sandusky sexually assaulting a boy in a shower. (AP Photo/Gene J. Puskar, File)
In this photo combo, at left, in an Oct. 8, 2011 file photo, Penn State president Graham Spanier walks on the field before an NCAA college football game in State College, Pa. At right, former Penn State University assistant football coach Jerry Sandusky leaves the Centre County Courthouse in custody after being found guilty of multiple charges of child sexual abuse in Bellefonte, Pa., Friday, June 22, 2012. CNN says it has seen emails showing Spanier agreed not to take allegations of sex abuse against Sandusky to authorities but worried they'd be "vulnerable" for failing to report it. CNN says the emails followed a graduate assistant's 2001 report of seeing Sandusky sexually assaulting a boy in a shower. (AP Photo/Gene J. Puskar, File)
STATE COLLEGE, Pa. (AP) ? Emails show Penn State's former president Graham Spanier agreed not to take allegations of sex abuse against ex-assistant football coach Jerry Sandusky to authorities but worried university officials would be "vulnerable" for failing to report it, a news organization has reported.
CNN says the emails, first obtained by and reported on by NBC, followed a graduate assistant's 2001 report of seeing Sandusky sexually assaulting a boy in a team locker room shower.
The emails show athletic director Tim Curley and retired vice president Gary Schultz intended to report the allegation, then reconsidered. Spanier responded that he was "supportive" of their plan, but he worried they might "become vulnerable for not having reported it."
Sandusky was convicted this month of 45 counts of sexually abusing 10 boys. The scandal led to the ouster of Spanier and revered coach Joe Paterno and charges against Curley and Schultz, who are accused of perjury for their grand jury testimony and failing to properly report suspected child abuse. Spanier hasn't been charged.
The CNN report cites an email from Schultz to Curley on Feb. 26, 2001, 16 days after graduate assistant Mike McQueary told veteran coach Joe Paterno about the shower assault. Schultz suggests bringing the allegation to the attention of Sandusky, Sandusky's charity and the Department of Welfare, which investigates suspected child abuse, according to the report.
But the next night, Curley sent an email to Spanier, saying that after thinking about it more and talking to Paterno, he was "uncomfortable" with that plan and wanted to work with Sandusky before contacting authorities, the report said.
If Sandusky is cooperative, Curley's email said, "we would work with him. .... If not, we do not have a choice and will inform the two groups," according to the report.
Spanier wrote back and agreed with that approach, calling it "humane and a reasonable way to proceed," according to the report. But he also worried about the consequences.
"The only downside for us is if message isn't 'heard' and acted upon and we then become vulnerable for not having reported it, but that can be assessed down the road," the email said, according to CNN.
Spanier's attorney didn't immediately return a call from The Associated Press seeking comment Saturday.
Schultz and Curley's lawyers on Saturday echoed recent comments by Gov. Tom Corbett about the need for a solid case before charging Sandusky. Corbett began the investigation in 2009 when he was attorney general.
"For Curley, Schultz, Spanier and Paterno, the responsible and 'humane' thing to do was, like Governor Corbett, to carefully and responsibly assess the best way to handle vague, but troubling allegations," the lawyers said. "Faced with tough situations, good people try to do their best to make the right decisions."
Paterno, ousted by the school's board of trustees for what was called his "failure of leadership" surrounding allegations against Sandusky, died of lung cancer in January. After Sandusky's arrest, Paterno said through a spokesman that he reported the allegation to the head of his department and "that was the last time the matter was brought to my attention until this investigation and I assumed that the men I referred it to handled the matter appropriately."
Schultz, 62, and Curley, 58, deny the allegations and have asked a judge to dismiss the charges. A status conference for their case is scheduled for July 11.
Spanier sued Penn State in May to try to get copies of his email traffic from 1998 to 2004, citing the pending investigation being conducted on the university by former FBI director Louis Freeh. Two weeks ago, lawyers for Penn State asked a judge to throw out the lawsuit and said the attorney general's office, which is prosecuting Curley and Schultz, had asked them not to provide Spanier with the emails.
Fox Sports - Andrew Luck not worried about not signing contract on time or holding out Indianapolis Colts fans shouldn?t worry that the team?s new franchise quarterback will remain unsigned at the start of training camp.That?s because Andrew Luck doesn?t sound worried.
CBS Sports - 2013 NFL Draft: Pittsburgh preview Considering their history of success on the collegiate gridiron as well as their penchant for churning out quality NFL prospects, there isn't a team in the Big East with a more impressive lineage than the Pitt Panthers. Questionable administrative decisions regarding the hiring and firing of coaches, as well as the team's movement next year to the ACC has stolen some of the spotlight from a once proud program.
NFL.com - Akiem Hicks becomes first Saints pick to reach deal The New Orleans Saints were the lone team yet to sign a draft pick -- until Thursday, when they announced they had agreed to terms on a four-year contract with third-rounder Akiem Hicks.
NFL Mocks - Kyle Fuller: 2013 NFL Draft scouting report Even before scouting Virginia Tech junior cornerback Kyle Fuller (remember, he is a junior so he might not enter the draft), I knew he was an underrated prospect (the film confirmed what I presumed).
Find Raptor 02 Homes For Sale and Raptor 02 Home Values. We also have information on mortgages, insurance, movers and other Treasure Coast Real Estate Services for anyone looking to sell or buy a home in beautiful St Lucie COUNTY Florida.
Paul Kitchen and Starfish Team provide clients, family and close friends with professional, honest and dependable service. A resident of Treasure Coast, Paul is extremely familiar with the local neighborhoods including Raptor 02, school districts and the Treasure Coast Real Estate market in this beautiful Florida town.
Paul Kitchen Broker-Owner Starfish Real Estate 8985 SE Bridge Road Hobe Sound, Florida 33455 (772) 539-8376 (800) 793-7304 toll free Treasure Coast Real Estate Treasure Coast Real Estate Blog
Season 7 of The Real Housewives of Orange County came to a screeching halt this week with a high-drama, two-part finale. The ladies of the OC are well known for their season-ending parties. Last year, we had the infamous drink-tossing incident between Jeana and Tamra. This year, not to be out-done, we had three incidents, starting with ?CakeGate?, when uninvited guest Sarah Winchester came to the party with Alexis. The party was a ?name-change? party thrown by Heather, who, after 15 years, decided to finally take her husband Terry Dubrow?s last name. What followed should make the highlight reels for the Real Housewives series! Alexis and Jim Bellino caused some drama during the Season 7 finale of The Real Housewives of Orange County. Image Credit: PRN / PR Photos. So the party is held at the palatial home of the Dubrows, where all of that plastic surgery money buys you a spectacular view of the Pacific Ocean and a home that princes and kings would feel comfortable in. Yet, Heather bought a cake for $550 that was hideous! Basically a three-tiered squarish cake with her new initials on it with a big pink sugar bow on top. Alexis arrives with [...]
(CNN) ? Dr. Stuart Fischbein chuckled when he read the title of the press release: ?Women with a fear of childbirth endure a longer labor.?
The release was promoting a study published this week in BJOG: An International Journal of Obstetrics and Gynecology. Researchers at Akershus University Hospital in Norway found women who feared giving birth were in labor for 1 hour and 32 minutes longer, on average, than those who had no fear.
?I?m glad there?s now evidence to say that,? Fischbein said, ?but it?s obvious.?
For those of us who aren?t OB/GYNs, it may seem more like a cruel joke. Women who are afraid of the pain and the possible medical complications associated with giving birth have to suffer through it longer?
Study author Dr. Samantha Salvesen Adams initially thought her team would find the prolonged labor could be explained by other factors ? women who feared birth the most were first time mothers, who are known to have longer labors anyway, or obstetric interventions like epidurals. But when those factors were taken into consideration, the difference in time between the fearless and the fearful was still 47 minutes.
?Mental stress is associated with physiological arousal and release of stress hormones,? Adams wrote in an e-mail. ?During labour, high levels of stress hormones may weaken uterine [contractions].?
In other words, the adrenaline released when a body is stressed stops the oxytocin hormone production that makes a woman?s uterus contract, slowing labor. It?s a natural, biological response to fear, Fischbein said.
Fischbein, who?s also a co-author of ?Fearless Pregnancy,? said women today are afraid of giving birth because they?re surrounded by horror stories.
?We have a society where sensationalism sells. They?re pounded with information [about] things that can go wrong with childbirth. Of course you develop fears.?
To understand Fischbein?s lack of surprise at the study results, you have to take a look at the way other mammals give birth. For example, when cats, dogs or horses are in labor, they find dark places to have their offspring in peace. They eat when they?re hungry, pace if they?re in pain and run if something comes near them.
Compare that to a hospital setting, where a woman is given ice chips, strapped to machines while laying in bed and surrounded by people who are constantly interrupting. Though the machines and medical personnel are sometimes necessary, Fischbein says the stress comes from being in an unfamiliar environment.
He recommends women find a doctor or midwife who will take the time to talk through their fears and dispense honest advice about the birthing process.
'; div.innerHTML = summary; } //]]> 7 Simple Tips for Finding the Right Business Broker7 Simple Tips for Finding the Right Business Broker
Article by Lyn Walker
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Undergraduate Student Summer Research Award recipients announced for the 2012 FASEB MARC summer research opportunity programPublic release date: 28-Jun-2012 [ | E-mail | Share ]
Contact: Jacquelyn Roberts marcsrop@faseb.org Federation of American Societies for Experimental Biology
Bethesda, MD FASEB MARC (Maximizing Access to Research Careers) Program has announced undergraduate student award recipients for the 2012 FASEB MARC Summer Research Opportunity Program (SROP). The FASEB MARC Program provide travel and subsistence awards for undergraduate students from underrepresented groups for summer research experiences in the laboratories of FASEB society members who serve as summer research mentors for the students. The FASEB MARC SROP provides funding to cover the travel and subsistence (transportation, lodging, and per diem) expenses for the undergraduate students, and contributes $500 towards the cost for the students' lab expenses. In addition, travel award funding is also available later in the year for the SROP students and their summer research mentors to participate in the Annual Biomedical Research Conference for Minority Students (ABRCMS) or an annual meeting of one of the FASEB member societies.
This year the FASEB MARC Program is sponsoring summer research experiences for 48 undergraduate students at 12 SROP host institutions for a total of $182,431. Thirty-six SROP mentors representing 12 FASEB member societies will be providing summer research experiences for the students over a ten-to-twelve-week period.
The FASEB MARC Program is funded by a grant from the National Institute of General Medical Sciences, National Institutes of Health. A primary goal of the MARC Program is to increase the number and competitiveness of underrepresented minorities engaged in biomedical and behavioral research.
2012 FASEB MARC Summer Research Opportunity Program (SROP)
List of SROP Host Mentors and FASEB MARC-Sponsored Undergraduate SROP Students
Howard University University
SROP Mentor: Georges Haddad [ASIP member]
SROP Student: Krystal Ealy, Syracuse University
Johns Hopkins Malaria Research Institute
SROP Mentor: Dr. Marcelo Jacobs-Lorena [GSA member]
SROP Student: Thomas Riley, University of Maryland, Baltimore County
Marshall University
SROP Mentor: Dr. Lawrence M. Grover [APS member]
SROP Student: Kelyn Pittman, Kennesaw State University
SROP Mentor: Dr. Nalini Santanam [ASBMB member]
SROP Student: Franklin Woode, Princeton University
New York University
SROP Mentor: Dr. Chiye Aoki [APS member]
SROP Student: Laura Bustamante, University of Pennsylvania
SROP Student: Melanie McNutt, Hampton University
SROP Student: Bianca Sigel, Tulane University
Rutgers University
SROP Mentor: Dr. Charles Roth [BMES member]
Orlando Barbosa, University of Puerto Rico, Mayaguez Campus
SROP Mentor: Dr. Victor Jin [AFMR member]
Kevin Chavez, Stony Brook University
SROP Mentor: Dr. Alberto Cuitino [SDB member]
Jonathan Colon, University of Puerto Rico, Mayaguez Campus
SROP Mentor: Dr. Emanuel DiCicco-Bloom [HCS member]
Alejandra Laureano, University of Puerto Rico, Rio Piedras Campus
SROP Mentor: Dr. Derek B Sant'Angelo [AAI member]
Crystal LeBlanc, Belmont University
SROP Mentor: Dr. Alan Goldman [SDB member]
Jose Martinez, Cornell College
SROP Mentor: Dr. Alberto Cuitino [SDB member]
Kevin Ortiz, University of Puerto Rico, Mayaguez Campus
SROP Mentor: Dr. Edward Selby [SDB member]
Andres Ramirez, Cornell University
SROP Mentor: Dr. Mladen Roko Rasin [SDB member]
Taylor Vega, University of California, Berkley
SROP Mentor: Dr. Stavroula Sofou [BMES member]
Justin Womack, University of Wisconsin, Madison
St. Jude Children's Research Hospital
SROP Mentor: Dr. Maureen McGargill [AAI member]
Ronald Valencia, University of North Carolina at Charlotte
SROP Mentor: Dr. Fatima Rivas [AFMR member]
Rachel Primacio, University of California, San Diego
SROP Mentor: Dr. Andrew M. Davidoff [AFMR member]
St. Jude Children's Research Hospital (continued)
Nicholas Thackaberry Gamboa, Gonzaga University
SROP Mentor: Dr. Richard Webby [AFMR member]
Ira Tigner Jr., Tuskegee University
Alexandria Broadnax, Dillard University
State University of New York at Buffalo
SROP Mentor: Dr. Derek Daniels [APS member]
Charity Bouyer, St. Johns University
SROP Mentor: Dr. Rajendram V. Rajnarayanan [ASPET member]
Joshua Legette, Tougaloo College
Donteeno Todd, Tougaloo College
SROP Mentor: Dr. Samir Haj-Dahmane [ASPET member]
Shukri Dualeh, University of Rochester
SROP Mentor: Dr. Margarita Dubocovich [ASPET member]
Angelica Rivera Gonzalez, University of Puerto Rico, Mayaguez Campus
SROP Mentor: Dr. Aiming Yu [ASPET member]
Brittney Browne, Fordham University
SROP Mentor: Dr. James Olson [ASPET member]
Danielle Forde-Riddick, Medgar Evers College - CUNY
SROP Mentor: Dr. Fraser Sim [ASPET member]
Kirsti Gilmore, Albany State University
SROP Mentor: Dr. Marilyn Morris [ASPET member]
Sharlene Robles, University of Puerto Rico, Aguadilla Campus
SROP Mentor: Dr. Maria Laura Feltri [SDB member]
Georgina Kemeh, City College of New York
SROP Mentor: Dr. Stewart Clark [ASPET member]
Diara Santiago-Gonzalez, University of Puerto Rico, Rio Piedras Campus
SROP Mentor: Dr. Caroline Bass [ASPET member]
Victoria Valdez, New Mexico Institute of Mining and Technology
University of Maryland Baltimore County
SROP Mentor: Dr. Michael Summers [ASBMB member]
SROP Student: Janae Baptiste, University of West Florida
SROP Student: Joshua Brown, University of West Florida
SROP Student: Olaniyan Jamal Cash,
Morehouse College
SROP Student: Mateo Hernandez, University of South Florida
SROP Student: Angelica McIntyre, The University of Southern Mississippi
SROP Student: Kamil Payano Sosa, Pennsylvania State University
SROP Student: Christy Taylor, University of Miami
SROP Student: Alexander Vega, University of West Florida
University of Tennessee Health Science Center
SROP Mentor: Dr. Ionnais Dragatsis [APS member]
SROP Student: Lavoryette Cannon, Xavier University
SROP Mentor: Dr.Kafait U. Malik [ASBMB member]
SROP Student: David Montanez, Vanderbilt University
University of Oregon
SROP Mentor: Dr. Scott Bridgham [ISCB member]
SROP Student: Tera Johnson, Skidmore College
University of Rochester
SROP Mentor: Dr. Lisa Opanashuk [TS member]
SROP Student: Kaitlyn Jefferson, University of South Dakota
Washington University in St. Louis
SROP Mentor: Dr. Shelia Stewart [ASBMB member]
SROP Student: Adrian Rivera, University of Puerto Rico, Rio Piedras Campus
###
FASEB is composed of 26 societies with more than 100,000 members, making it the largest coalition of biomedical research associations in the United States. Celebrating 100 Years of Advancing the Life Sciences in 2012, FASEB is rededicating its efforts to advance health and well-being by promoting progress and education in biological and biomedical sciences through service to our member societies and collaborative advocacy.
[ | E-mail | Share ]
?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Undergraduate Student Summer Research Award recipients announced for the 2012 FASEB MARC summer research opportunity programPublic release date: 28-Jun-2012 [ | E-mail | Share ]
Contact: Jacquelyn Roberts marcsrop@faseb.org Federation of American Societies for Experimental Biology
Bethesda, MD FASEB MARC (Maximizing Access to Research Careers) Program has announced undergraduate student award recipients for the 2012 FASEB MARC Summer Research Opportunity Program (SROP). The FASEB MARC Program provide travel and subsistence awards for undergraduate students from underrepresented groups for summer research experiences in the laboratories of FASEB society members who serve as summer research mentors for the students. The FASEB MARC SROP provides funding to cover the travel and subsistence (transportation, lodging, and per diem) expenses for the undergraduate students, and contributes $500 towards the cost for the students' lab expenses. In addition, travel award funding is also available later in the year for the SROP students and their summer research mentors to participate in the Annual Biomedical Research Conference for Minority Students (ABRCMS) or an annual meeting of one of the FASEB member societies.
This year the FASEB MARC Program is sponsoring summer research experiences for 48 undergraduate students at 12 SROP host institutions for a total of $182,431. Thirty-six SROP mentors representing 12 FASEB member societies will be providing summer research experiences for the students over a ten-to-twelve-week period.
The FASEB MARC Program is funded by a grant from the National Institute of General Medical Sciences, National Institutes of Health. A primary goal of the MARC Program is to increase the number and competitiveness of underrepresented minorities engaged in biomedical and behavioral research.
2012 FASEB MARC Summer Research Opportunity Program (SROP)
List of SROP Host Mentors and FASEB MARC-Sponsored Undergraduate SROP Students
Howard University University
SROP Mentor: Georges Haddad [ASIP member]
SROP Student: Krystal Ealy, Syracuse University
Johns Hopkins Malaria Research Institute
SROP Mentor: Dr. Marcelo Jacobs-Lorena [GSA member]
SROP Student: Thomas Riley, University of Maryland, Baltimore County
Marshall University
SROP Mentor: Dr. Lawrence M. Grover [APS member]
SROP Student: Kelyn Pittman, Kennesaw State University
SROP Mentor: Dr. Nalini Santanam [ASBMB member]
SROP Student: Franklin Woode, Princeton University
New York University
SROP Mentor: Dr. Chiye Aoki [APS member]
SROP Student: Laura Bustamante, University of Pennsylvania
SROP Student: Melanie McNutt, Hampton University
SROP Student: Bianca Sigel, Tulane University
Rutgers University
SROP Mentor: Dr. Charles Roth [BMES member]
Orlando Barbosa, University of Puerto Rico, Mayaguez Campus
SROP Mentor: Dr. Victor Jin [AFMR member]
Kevin Chavez, Stony Brook University
SROP Mentor: Dr. Alberto Cuitino [SDB member]
Jonathan Colon, University of Puerto Rico, Mayaguez Campus
SROP Mentor: Dr. Emanuel DiCicco-Bloom [HCS member]
Alejandra Laureano, University of Puerto Rico, Rio Piedras Campus
SROP Mentor: Dr. Derek B Sant'Angelo [AAI member]
Crystal LeBlanc, Belmont University
SROP Mentor: Dr. Alan Goldman [SDB member]
Jose Martinez, Cornell College
SROP Mentor: Dr. Alberto Cuitino [SDB member]
Kevin Ortiz, University of Puerto Rico, Mayaguez Campus
SROP Mentor: Dr. Edward Selby [SDB member]
Andres Ramirez, Cornell University
SROP Mentor: Dr. Mladen Roko Rasin [SDB member]
Taylor Vega, University of California, Berkley
SROP Mentor: Dr. Stavroula Sofou [BMES member]
Justin Womack, University of Wisconsin, Madison
St. Jude Children's Research Hospital
SROP Mentor: Dr. Maureen McGargill [AAI member]
Ronald Valencia, University of North Carolina at Charlotte
SROP Mentor: Dr. Fatima Rivas [AFMR member]
Rachel Primacio, University of California, San Diego
SROP Mentor: Dr. Andrew M. Davidoff [AFMR member]
St. Jude Children's Research Hospital (continued)
Nicholas Thackaberry Gamboa, Gonzaga University
SROP Mentor: Dr. Richard Webby [AFMR member]
Ira Tigner Jr., Tuskegee University
Alexandria Broadnax, Dillard University
State University of New York at Buffalo
SROP Mentor: Dr. Derek Daniels [APS member]
Charity Bouyer, St. Johns University
SROP Mentor: Dr. Rajendram V. Rajnarayanan [ASPET member]
Joshua Legette, Tougaloo College
Donteeno Todd, Tougaloo College
SROP Mentor: Dr. Samir Haj-Dahmane [ASPET member]
Shukri Dualeh, University of Rochester
SROP Mentor: Dr. Margarita Dubocovich [ASPET member]
Angelica Rivera Gonzalez, University of Puerto Rico, Mayaguez Campus
SROP Mentor: Dr. Aiming Yu [ASPET member]
Brittney Browne, Fordham University
SROP Mentor: Dr. James Olson [ASPET member]
Danielle Forde-Riddick, Medgar Evers College - CUNY
SROP Mentor: Dr. Fraser Sim [ASPET member]
Kirsti Gilmore, Albany State University
SROP Mentor: Dr. Marilyn Morris [ASPET member]
Sharlene Robles, University of Puerto Rico, Aguadilla Campus
SROP Mentor: Dr. Maria Laura Feltri [SDB member]
Georgina Kemeh, City College of New York
SROP Mentor: Dr. Stewart Clark [ASPET member]
Diara Santiago-Gonzalez, University of Puerto Rico, Rio Piedras Campus
SROP Mentor: Dr. Caroline Bass [ASPET member]
Victoria Valdez, New Mexico Institute of Mining and Technology
University of Maryland Baltimore County
SROP Mentor: Dr. Michael Summers [ASBMB member]
SROP Student: Janae Baptiste, University of West Florida
SROP Student: Joshua Brown, University of West Florida
SROP Student: Olaniyan Jamal Cash,
Morehouse College
SROP Student: Mateo Hernandez, University of South Florida
SROP Student: Angelica McIntyre, The University of Southern Mississippi
SROP Student: Kamil Payano Sosa, Pennsylvania State University
SROP Student: Christy Taylor, University of Miami
SROP Student: Alexander Vega, University of West Florida
University of Tennessee Health Science Center
SROP Mentor: Dr. Ionnais Dragatsis [APS member]
SROP Student: Lavoryette Cannon, Xavier University
SROP Mentor: Dr.Kafait U. Malik [ASBMB member]
SROP Student: David Montanez, Vanderbilt University
University of Oregon
SROP Mentor: Dr. Scott Bridgham [ISCB member]
SROP Student: Tera Johnson, Skidmore College
University of Rochester
SROP Mentor: Dr. Lisa Opanashuk [TS member]
SROP Student: Kaitlyn Jefferson, University of South Dakota
Washington University in St. Louis
SROP Mentor: Dr. Shelia Stewart [ASBMB member]
SROP Student: Adrian Rivera, University of Puerto Rico, Rio Piedras Campus
###
FASEB is composed of 26 societies with more than 100,000 members, making it the largest coalition of biomedical research associations in the United States. Celebrating 100 Years of Advancing the Life Sciences in 2012, FASEB is rededicating its efforts to advance health and well-being by promoting progress and education in biological and biomedical sciences through service to our member societies and collaborative advocacy.
[ | E-mail | Share ]
?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
When I was on my travels in the lovely St Lucia, I embarked on some light pool time reading - the abs diet! Luckily this was the perfect time to read it - no other distractions (apart from when the next mango daiquiri was going to arrive) meant I could read it from top to bottom and really discover how potentially brilliant a book it actually was.
So, I started the diet three weeks ago today, and although I'm going to post properly once the 6 weeks is up, it's nice to recap half way in.
I felt and actually SAW results almost instantly - within a week I'd lost half an inch from my waist and could see actual improvements in my 'one pack'. I also loved the eating plan from the get go and feel every day I am getting enough food and enough nutrients to never feel hungry, deprived or like my body isn't getting what it needs.
I explained briefly what the premiss is a few posts ago, and am finding this style of eating pretty much spot on for me. It is (dare I say it) perfect.
A typical day looks like this: Breakfast of a smoothie made from berries, milk, protein powder and add in's such as flax A mid morning snack of natural yogurt and an apple Lunch of salad with sliced turkey and chopped veggies, followed by an orange Afternoon snackies of an ounce of almonds and strawberries Post workout snack of a protein shake blended with milk and berries Evening meal of meatballs made with lamb, a homemade tomato sauce and whole wheat pasta. Throughout the day - shed loads of water and tea :)
I'm hitting my 5 a day without evening trying and my food feels so much more balanced. I no longer really think about having something sweet after my evening meal - it's not part of the plan (unless it's my cheat meal!) so I don't even crave it. Yes - on to the cheat meal! Once a week, the plan suggests you eat literally anything you fancy for one meal. It apparently trips your metabolism into working harder for that one meal, and of course is a bloody great big treat :) So, for that meal I have been having whatever I fancy along with some sort of dessert and a few drinkies.
I can't wait to see how I feel in the next few weeks. I am beginning to wonder, why on earth did I not think of this before??
'Ozone Pollution Bad News For Heart Patients' - Medical News Today June 27, 2012
Zee News'Ozone Pollution Bad News For Heart Patients'Medical News TodayA Study published in the journal Circulation shows Ozone pollution having a marked effect on those at high risk for heart attack. The World Health organization estimated that some 2 million people die annually due to a combination of heart problems ...Ozone: Heart of the matterS [?]
Pennsylvania woman to address FDA panel on husband's hip-replacement recall - Philadelphia Inquirer June 27, 2012
U.S. News & World ReportPennsylvania woman to address FDA panel on husband's hip-replacement recallPhiladelphia InquirerSteve Lorenz works as a foreman at a cement company near his home in Whitehall, Pa., and has been active all of his life, but that life has been different since he had both hips replaced. "Sitting with him, watching TV, he wou [?]
Mild exercise may reduce breast cancer - UPI.com June 27, 2012
CBS NewsMild exercise may reduce breast cancerUPI.comCHAPEL HILL, NC, June 27 (UPI) -- Exercise -- either mild or intense, before or after menopause -- may reduce breast cancer risk, but weight gain may negate the benefit, US researchers say. The study, published online ahead of the print edition of the ...Regular Exercise Can Help Lower Breast Cancer RiskTI [?]
Doctors urged to send the obese for high-intensity help - Ctv News June 27, 2012
Ctv NewsDoctors urged to send the obese for high-intensity helpCtv NewsAP Body mass index signals if you're overweight, obese or just right considering your height. Some doctors have begun calling it a vital sign, as crucial to monitor as blood pressure. But apparently not enough doctors check: A government panel renewed ...Obese adults should get couns [?]
CDC program aims to make HIV testing the norm - San Francisco Chronicle June 27, 2012
San Francisco ChronicleCDC program aims to make HIV testing the normSan Francisco ChronicleAP Walgreen's pharmacy manager Sarah Freedman stands in her store in Washington, Tuesday, June 26, 2012. Would you go to a pharmacy to get tested for the AIDS virus? Health officials want to know. The Centers for Disease Control and Prevention on ...AIDS is forgot [?]
Exposure to Secondhand Smoke May Increase Chance of Developing Type 2 Diabetes ... - Forbes June 27, 2012
Zee NewsExposure to Secondhand Smoke May Increase Chance of Developing Type 2 Diabetes ...ForbesNEW YORK, NY - MAY 23: A woman smokes a cigarette in the pedestrian plaza located in Times Square May 23, 2011 in New York City. A new smoking law took effect in New York City Monday, prohibiting smokers from lighting up in certain public places ...Secondhand Smok [?]
Women's lung cancer deaths up in South and Midwest - Reuters June 26, 2012
GPBWomen's lung cancer deaths up in South and MidwestReutersBy Natasja Sheriff | NEW YORK (Reuters Health) - Despite falling lung cancer rates across the US in the past decade, researchers report that deaths from the disease are steady or rising among middle-aged women in southern and Midwestern states.Women's lung cancer deaths up in parts of US: [?]
Not All Calories Equal, Study of 3 Diets Shows - Wall Street Journal June 26, 2012
The AgeNot All Calories Equal, Study of 3 Diets ShowsWall Street JournalBy JENNIFER CORBETT DOOREN A diet based on healthy carbohydrates?rather than a low-fat or low-carbohydrate diet?offers the best chance of keeping weight off without bringing unwanted side effects, a study published Tuesday in the Journal of the ...Low-carb diet burns the most calories in [?]
Role of stress in dementia investigated - BBC News June 26, 2012
CBS NewsRole of stress in dementia investigatedBBC NewsBy Michelle Roberts Health editor, BBC News online UK experts are to begin a study to find out if stress can trigger dementia. The investigation, funded by the Alzheimer's Society, will monitor 140 people with mild cognitive impairment or ...Study to explore link between chronic stress and Alzheimer [?]
EEG brain trace 'can detect autism' - BBC News June 26, 2012
BBC NewsEEG brain trace 'can detect autism'BBC NewsBy Michelle Roberts Health editor, BBC News online A simple brain trace can identify autism in children as young as two years old, scientists believe. A US team at Boston Children's Hospital say EEG traces, which record electrical brain activity using ...How Might Autistic Children Be Similar? [?]
26 June 2012Last updated at 04:53 ETBy Mark KinverEnvironment reporter, BBC News
UK homes are consuming much more electricity than previously estimated, a report described as the most detailed of its kind has suggested.
For example, it found that up to 16% of households' energy bills are spent on devices left on standby.
It is estimated that domestic energy use accounts for more than a quarter of the nation's CO2 emissions.
The report was commissioned by the government and the Energy Saving Trust to unearth the nation's energy habits.
"This standby power is double what we have assumed it to be in past models and policy assumptions," explained Paula Owen, the report's lead author.
"Before, we have always gone with an 8% figure so it was quite a shock."
Within in this study, Dr Owen explained, standby had a slightly wider remit from its traditional perception of the red lights on TVs and videos.
"When we talk about standby in this context, we are talking about things that are on standby and things [that] are idle, rather than [doing] what they are primarily designed to do," she said.
The modern home contained an average of 41 devices, compared with a dozen or so in the 1970s.
The UK year-long study, commissioned by EST, the Department for Environment, Food and Rural Affairs (Defra) and the Department for Energy and Climate Change (Decc), involved more than 250 households.
Only two previous studies of its kind have been carried out before.
In 2008, Sweden detailed the electricity consumption of 400 households, while a study in France considered the use in 100 homes during 2007.
'Don't live alone'
Dr Owen explained: "One of the more surprising findings from the study is the amount of use from single occupancy households, which were shown to be using as much as, even more than, as family occupied homes."
Another insight was the use of washing machines, which varied greatly across the sample group, Dr Owen said.
"Typically, people use their washing machine 300 times a year; we found that there were some people who were using it three time a day.
"So there is a lot of evidence in this report that shows how people are using their electrical equipment, as well as how often they are using it."
Philip Sellwood, chief executive of the Energy Saving Trust (EST), said that it was "crucial that households across the nation make informed decisions by having the right advice to help them reduce their energy usage and fuel bills".
"This research shows that there's still more work to be done with consumer advice, product innovation and take up of energy-efficiency labelling," he said.
Environment minister Lord Taylor said the government and households could not control the rising cost of energy but could play a part in ensuring that it was used more efficiently.
"Our study has found that homes can save up to ?85 by just switching things off and not leaving them on standby," he said.
"Some savings can be made by us, as individuals, by just being more sensible in the way we use energy."
Dr Owen said a big issue for the future would be the increasing popularity of electric vehicles.
"This will dramatically increase our pull on the grid," she told BBC News.
"That is the big growth area over the coming decades, if electric cars do become popular, so we need to see offsets in the domestic setting in order to allow us to power our vehicles in the future."
Rosalyn Foreman, energy adviser for the EST, explained that there were still traditional areas where their efforts could be focused.
"The fridge and the freezer in a house are the real energy eaters. They are the ones that can make a real difference, and it is easier to target the consumer on buying a better appliance.
"It is areas like this where you can make a difference and influence people.
"But we have never had the evidence down to this level of detail before, so it gives us an insight into what we can target and how we target it."
The bad news: if you've been hoping to grab a Droid Incredible 4G LTE so you can show it off to your friends at your local July 4th extravaganza, you're out of luck. The good news: you might be able to cheer up from your post-holiday depression the very next day. According to internal employee docs captured by Droid-Life, we should expect Verizon's first Sense 4 device to arrive at stores on July 5th for $200 with a two-year contract. As always, pricing and availability are never set in stone; after all, internal employee docs gave us false hope that the Motorola Droid 4 would show up several weeks before it actually launched, but that was likely a result of Verizon pulling the launch at the last minute. Provided Big Red doesn't change its mind (or other snafus throw a wrench into the process), we won't be disappointed this time around.
For every step Facebook takes toward improving consumer privacy and information control, it seems to take about five giant steps back. The latest example is the unilateral change it made to users' listed email addresses: It converted them to @facebook.com, and messages now go to the Facebook email in-box rather than to their original destinations.
ScienceDaily (June 25, 2012) ? As the world fights obesity at the human level, scientists at the University of Michigan and their colleagues have made a surprising finding at the microscopic level that could help fuel that fight.
Their work helps explain why fat-storing cells get fatter, and burn fat slower, as obesity sets in. If their findings from mice can be shown to apply to humans, they may provide a new target for obesity-fighting drugs.
By studying the tiny signals that fat-storing cells send to one another, the team has shown a crucial and previously unknown role for a molecule called Sfrp5.
The results, which appear online June 25 and will be in the July issue of the Journal of Clinical Investigation, surprised them.
In a series of experiments, the team showed that Sfrp5 influences a signaling pathway known as WNT to stimulate fat cells -- called adipocytes -- to grow larger and to suppress the rate at which fat is burned in the mitochondria inside them.
By stopping cells from making Sfrp5, they were able to make mice that didn't get as fat as quickly because their adipocytes didn't grow large -- even when the mice were fed a high-fat diet. They even showed the impact when transplanting fat from Sfrp5 -- deficient mice into other mice.
The research was performed with National Institutes of Health funding in the U-M Medical School laboratory of Ormond MacDougald, Ph.D., the Faulkner Professor in the Department of Molecular & Integrative Physiology, a professor of internal medicine and a member of U-M's Brehm Center for Diabetes Research.
Working with postdoctoral fellow and first author Hiroyuki Mori, Ph.D., and colleagues, MacDougald says the team built on its previous findings about the importance of WNT signaling in fat cell development.
"WNT signaling plays a crucial role in regulating, and inhibiting, white fat cell growth and the recruitment of new cells to store fat," he explains. "But it appears that in obesity, Sfrp5 can interfere with that signaling, and may create a feedback loop that keeps stimulating production of more of itself."
He notes that the new results contradict previous work published by another group, which found essentially the opposite role for Sfrp5. A commentary accompanying the new U-M paper, by scientists from Denmark, notes the strong evidence behind the new findings and emphasizes the importance of further research on the topic.
MacDougald and his team zeroed in on Sfrp5 after years of studying WNT signaling between adipocytes. They and other teams had already seen that the amounts of Sfrp5 produced within fat tissue were higher in obese animals.
They were able to breed mice that could not make the molecule, and expected to see that these mice resisted obesity because they couldn't convert more cells into adipocytes to store excess fat from their high-fat diet.
But instead, they found that the mice without Sfrp5 did have just as many fat cells as other mice -- but that these cells didn't accumulate fat and grow bigger. As a result, the mice didn't get fat, no matter how rich their diet.
Looking more closely at Sfrp5-deficient mice, they saw a surge of activity in expression of genes related to mitochondria -- the furnaces inside cells that burn fat or other fuel to power cell activity. It was as if the furnaces had been stoked when Sfrp5 wasn't present, so fat could be burned at a higher rate than normal.
"From our results, we believe that Sfrp5 is an important moderator of mitochondrial activity, the first time this has been seen for the WNT signaling pathway in adipocytes," says Mori. "This underscores the complexity of WNT signaling."
In essence, MacDougald says, Sfrp5 poses as a decoy receptor for WNT signals to bind to, keeping them from binding to the receptors on the cell surface that they otherwise would bind to. With WNT signaling reduced, cells store fat and grow larger, and don't burn it as quickly. Then, the cells produce even more Sfrp5, creating the feedback loop that perpetuates the tendency for adipocytes to accumulate lipid.
While pharmaceutical companies are already looking at WNT signaling as a possible target for drugs related to bone formation, the new findings suggest that perhaps the same signaling pathway could be a target for anti-obesity drugs.
But, MacDougald cautions, the findings need to be explored further in both mice and humans. With the obesity epidemic putting hundreds of millions of people at risk of all types of diseases, that research has a special urgency behind it.
In addition to MacDougald and Mori, the research team included Tyler C. Prestwich, who received a Ph.D. from U-M's Cell and Molecular Biology program and is a co-first author, Michael A. Reid, former U-M postdoctoral fellow and Proteostasis Therapeutics employee Kenneth Longo, former postdoctoral fellow Isabelle Gerin, current fellow William Cawthorn, Vedrana S. Susulic, Venkatesh Krishnan, and Andy Greenfield.
The work was supported by grants DK51563 and DK62876 from the NIH's National Institute for Diabetes and Digestive and Kidney Diseases, and by Mori's mentor-based postdoctoral fellowship from the American Diabetes Association. The team used two core research facilities at the U-M Medical School: the Animal Phenotyping Core of the Nutrition Obesity Research Center, supported by NIH grant DK089503, and the Morphology Core of the Michigan Diabetes Research and Training Center, supported by NIH grant P60DK020572.
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Story Source:
The above story is reprinted from materials provided by University of Michigan Health System.
Note: Materials may be edited for content and length. For further information, please contact the source cited above.
Journal Reference:
Hiroyuki Mori, Tyler C. Prestwich, Michael A. Reid, Kenneth A. Longo, Isabelle Gerin, William P. Cawthorn, Vedrana S. Susulic, Venkatesh Krishnan, Andy Greenfield, Ormond A. MacDougald. Secreted frizzled-related protein 5 suppresses adipocyte mitochondrial metabolism through WNT inhibition. Journal of Clinical Investigation, 2012; DOI: 10.1172/JCI63604
Note: If no author is given, the source is cited instead.
Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.
A two-day conference at St Mary?s University College, Twickenham, to launch a major new research project by the European Society for Catholic Theology (ESCT). Organized in conjunction with Heythrop College, University of London, and the Centre for Catholic Studies, Durham University.
4 Tuesday ? 5 Wednesday September 2012
Confirmed speakers (more to be added):
* Rt. Revd John Arnold (Auxiliary Bishop, Westminster)
* Prof. John Bell (University of Cambridge)
* Prof. Annemie Dillen (KU Leuven)
* Mary Kenny (Irish Independent, Irish Catholic)
* Revd Dr Dariusz Krok (Opole University)
* Mgr Charles Scicluna (Congregation for the Doctrine of the Faith)
* Madeleine Teahan (Catholic Herald)
Conference aims
? The aim of the event is to bring together researchers from a wide range of disciplines, interested in: a) examining the nature, scope, and context of abuses of power, both in the Church and beyond; and b) investigating the means by which they may be overcome.
? While the sexual abuse crisis will naturally form a major focus of the conference (and project), this cannot be understood within a vacuum. We are therefore keen to explore all other issues relating to the topic of theology, power, and abuse.
? The conference will identify a number of key themes that will guide and inform the Redeeming Power project over the next two years, leading to a number of events, projects and publications across Europe.
Call for Papers
Significant time has been set aside in the conference schedule for short papers (i.e., 20 mins) and discussion. Established and emerging scholars from a wide range of disciplines ? including, but not limited to, theology, philosophy, psychology, sociology, social work, history, and law (canon and secular) ? are strongly encouraged to consider submitting a proposal.
Abstracts (no more than 250 words) of proposed topics should be sent to Dr Stephen Bullivant at stephen.bullivant@smuc.ac.uk by Friday, 13 July.
Decisions will be communicated by Friday, 20 July.
Registration
Full conference information (e.g., full schedule), and details on how to
register, will be made available on the project website:
http://www.smuc.ac.uk/inspire/redeeming-power.htm by the end of June. It
is hoped that the conference fee (inc. meals, and accommodation on 4
Sept.) will be in the region of ?140-150 (TBC). Small bursaries may also
be available for postgraduate students giving short paper. Please
address all queries to Stephen Bullivant.
Redeeming Power is a joint venture between the ESCT and scholars at
University College Dublin (Ireland), Durham University (UK), Heythrop
College (UK), KU Leuven (Belgium), University of Opole (Poland), St
Mary?s University College (UK), and University of Trnava (Slovakia)
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This topic is an Out Of Character part of the roleplay, ?Creatures?. Anything posted here will also show up there.
Topic Tags:
Forum for completely Out of Character (OOC) discussion, based around whatever is happening In Character (IC). Discuss plans, storylines, and events; Recruit for your roleplaying game, or find a GM for your playergroup.
This roleplay sounds incredibly interesting, but I make a rule not to join roleplays that reserve characters in pairings when the roleplay's plot is not central to those pairings. I apologize for not being able to join in on this, but with your inability to offer less conventional pairings (transgenders or homosexual pairings) and your reserves in pairs, I will have to abstain. Thank you for the ideas from this wonderful roleplay, though.
Tom Ice
Member for 1 years
Thank you for the input but I would appreciate it if you don't steel my ideas.
ScarnyLuv
Member for 0 years
You flatter yourself, dear.
Tom Ice
Member for 1 years
Post a reply
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Boosting blood system protein complex protects against radiation toxicityPublic release date: 24-Jun-2012 [ | E-mail | Share ]
Contact: Nick Miller nicholas.miller@cchmc.org 513-803-6035 Cincinnati Children's Hospital Medical Center
CINCINNATI - New research in Nature Medicine shows that boosting a protein pathway in the body's blood making system protects mice from otherwise fatal radiation poisoning.
Scientists in the multi-institutional study posted online by the journal on June 24 say their findings open the potential for new treatments against radiation toxicity during cancer treatment or environmental exposures such as in a nuclear explosion or accident.
By identifying a target-specific intervention to protect the hematopoietic system against radiation toxicity, the study addresses a largely unmet challenge, according to the researchers.
"These findings suggest that pharmacologic augmentation of the activity of the Thbd-aPC pathway by recombinant Thbd (thrombomodulin) or aPC (activated protein C) might offer a rational approach to the mitigation of tissue injury and lethality caused by ionizing radiation," the scientists write in their manuscript. "Recombinant human aPC has undergone extensive clinical testing in patients, and recombinant soluble human Thbd is currently being investigated for efficacy in antithrombotic therapy in humans. Our data encourage the further evaluation of these proteins for their radio-mitigating activities."
The study reveals a previously unknown function of the Thbd-aPC pathway in radiation mitigation. The pathway is normally known for its ability to prevent the formation of blood clots and help the body fight infections. The researchers found the pathway helps blood cells in the bone marrow recover from injury caused by radiation exposure. They demonstrated that pharmacologic boosting of this pathway with two drugs tested for the treatment of thrombosis or infection (recombinant Thbd and aPC respectively) can be used in mice to prevent death caused by exposure to lethal doses of radiation.
In all instances of treatment with recombinant soluble Thbd or aPC, the result was accelerated recovery of hematopoietic progenitor cell activity in bone marrow and a reduction in the harmful effects of lethal total body irradiation. When treatment was with aPC, these benefits occurred even when treatment was delayed for 24 hours.
The scientists caution their study involves early laboratory research in mice, so it remains to be tested how the findings may translate to human treatment. Researchers also need to determine exactly why the protective function of the targeted Thbd-aPC protein pathway seems to work so well in mice.
Researchers noted that the protective benefits of Thbd-aPC occurred only in vivo in irradiated mouse models. The researchers reported that overexpressed Thbd in irradiated laboratory cell cultures did not offer the same protective benefits, as the cells did not survive. This indicates the protective benefits of Thbd on blood making cells in irradiated mouse models depends on the help of additional cells or molecules in the body, which the researchers are trying to identify in a follow-up study.
The study involves extensive multi-scientist collaborations that combined previously independent lines of research by groups at Cincinnati Children's Hospital Medical Center and the University of Ulm, Germany (led by Hartmut Geiger, PhD, Division of Experimental Hematology/Cancer Biology and the Department of Dermatology/Allergic Diseases); the University of Arkansas, Little Rock (led by Martin Hauer-Jensen, MD, PhD, Division of Radiation Health, the College of Pharmacy and the Central Arkansas Veterans Healthcare System); the Blood Research Institute in Milwaukee, Wis. (led by Hartmut Weiler, PhD); and The Scripps Research Institute in La Jolla, Calif. (led by John H. Griffin, PhD, Department of Molecular and Experimental Medicine).
The research team said the current study exemplifies a global shift to multi-investigator projects that allow a combination of varied expertise by scientists tackling complex problems from the perspective of their respective fields. This approach requires the willingness of investigators to share unpublished data and engage in an open collaboration. The researchers also said the study underscores the importance of continued federal funding for leading edge basic research that can benefit human health.
###
The study was supported by funding from The National Institutes of Health, as well as the U.S. Department of Veterans Affairs and the Edward P. Evans Foundation.
Additional co-authors on the study include Snehalata A. Pawar, Edward J. Kerschen, Kalpana J. Nattamai, Irene Hernandez, Hai-Po Liang, Jose A. Fernandez, Jose A. Cancelas, Marnie A. Ryan, Olga Kustikova, Axel Schambach, Qiang Fu, Junru Wang, Louis M. Fink, Karl-Uwe Petersen, Daohong Zhou and Christopher Baum, and the following institutions: Department of Experimental Hematology, Hannover Medical School, Hannover, Germany; the Desert Research Institute, Las Vegas, Nev.; PAION Deutschland GmbH, Aachen, Germany.
About Cincinnati Children's:
Cincinnati Children's Hospital Medical Center ranks third in the nation among all Honor Roll hospitals in U.S. News and World Report's 2012 Best Children's Hospitals ranking. It is ranked #1 for neonatology and in the top 10 for all pediatric specialties. Cincinnati Children's is one of the top two recipients of pediatric research grants from the National Institutes of Health. It is internationally recognized for improving child health and transforming delivery of care through fully integrated, globally recognized research, education and innovation. Additional information can be found at www.cincinnatichildrens.org.
[ | E-mail | Share ]
?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Boosting blood system protein complex protects against radiation toxicityPublic release date: 24-Jun-2012 [ | E-mail | Share ]
Contact: Nick Miller nicholas.miller@cchmc.org 513-803-6035 Cincinnati Children's Hospital Medical Center
CINCINNATI - New research in Nature Medicine shows that boosting a protein pathway in the body's blood making system protects mice from otherwise fatal radiation poisoning.
Scientists in the multi-institutional study posted online by the journal on June 24 say their findings open the potential for new treatments against radiation toxicity during cancer treatment or environmental exposures such as in a nuclear explosion or accident.
By identifying a target-specific intervention to protect the hematopoietic system against radiation toxicity, the study addresses a largely unmet challenge, according to the researchers.
"These findings suggest that pharmacologic augmentation of the activity of the Thbd-aPC pathway by recombinant Thbd (thrombomodulin) or aPC (activated protein C) might offer a rational approach to the mitigation of tissue injury and lethality caused by ionizing radiation," the scientists write in their manuscript. "Recombinant human aPC has undergone extensive clinical testing in patients, and recombinant soluble human Thbd is currently being investigated for efficacy in antithrombotic therapy in humans. Our data encourage the further evaluation of these proteins for their radio-mitigating activities."
The study reveals a previously unknown function of the Thbd-aPC pathway in radiation mitigation. The pathway is normally known for its ability to prevent the formation of blood clots and help the body fight infections. The researchers found the pathway helps blood cells in the bone marrow recover from injury caused by radiation exposure. They demonstrated that pharmacologic boosting of this pathway with two drugs tested for the treatment of thrombosis or infection (recombinant Thbd and aPC respectively) can be used in mice to prevent death caused by exposure to lethal doses of radiation.
In all instances of treatment with recombinant soluble Thbd or aPC, the result was accelerated recovery of hematopoietic progenitor cell activity in bone marrow and a reduction in the harmful effects of lethal total body irradiation. When treatment was with aPC, these benefits occurred even when treatment was delayed for 24 hours.
The scientists caution their study involves early laboratory research in mice, so it remains to be tested how the findings may translate to human treatment. Researchers also need to determine exactly why the protective function of the targeted Thbd-aPC protein pathway seems to work so well in mice.
Researchers noted that the protective benefits of Thbd-aPC occurred only in vivo in irradiated mouse models. The researchers reported that overexpressed Thbd in irradiated laboratory cell cultures did not offer the same protective benefits, as the cells did not survive. This indicates the protective benefits of Thbd on blood making cells in irradiated mouse models depends on the help of additional cells or molecules in the body, which the researchers are trying to identify in a follow-up study.
The study involves extensive multi-scientist collaborations that combined previously independent lines of research by groups at Cincinnati Children's Hospital Medical Center and the University of Ulm, Germany (led by Hartmut Geiger, PhD, Division of Experimental Hematology/Cancer Biology and the Department of Dermatology/Allergic Diseases); the University of Arkansas, Little Rock (led by Martin Hauer-Jensen, MD, PhD, Division of Radiation Health, the College of Pharmacy and the Central Arkansas Veterans Healthcare System); the Blood Research Institute in Milwaukee, Wis. (led by Hartmut Weiler, PhD); and The Scripps Research Institute in La Jolla, Calif. (led by John H. Griffin, PhD, Department of Molecular and Experimental Medicine).
The research team said the current study exemplifies a global shift to multi-investigator projects that allow a combination of varied expertise by scientists tackling complex problems from the perspective of their respective fields. This approach requires the willingness of investigators to share unpublished data and engage in an open collaboration. The researchers also said the study underscores the importance of continued federal funding for leading edge basic research that can benefit human health.
###
The study was supported by funding from The National Institutes of Health, as well as the U.S. Department of Veterans Affairs and the Edward P. Evans Foundation.
Additional co-authors on the study include Snehalata A. Pawar, Edward J. Kerschen, Kalpana J. Nattamai, Irene Hernandez, Hai-Po Liang, Jose A. Fernandez, Jose A. Cancelas, Marnie A. Ryan, Olga Kustikova, Axel Schambach, Qiang Fu, Junru Wang, Louis M. Fink, Karl-Uwe Petersen, Daohong Zhou and Christopher Baum, and the following institutions: Department of Experimental Hematology, Hannover Medical School, Hannover, Germany; the Desert Research Institute, Las Vegas, Nev.; PAION Deutschland GmbH, Aachen, Germany.
About Cincinnati Children's:
Cincinnati Children's Hospital Medical Center ranks third in the nation among all Honor Roll hospitals in U.S. News and World Report's 2012 Best Children's Hospitals ranking. It is ranked #1 for neonatology and in the top 10 for all pediatric specialties. Cincinnati Children's is one of the top two recipients of pediatric research grants from the National Institutes of Health. It is internationally recognized for improving child health and transforming delivery of care through fully integrated, globally recognized research, education and innovation. Additional information can be found at www.cincinnatichildrens.org.
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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
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Public release date: 28-Jun-2012
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